Acute psychological stress increases serum circulating cell-free mitochondrial DNA
نویسندگان
چکیده
منابع مشابه
Cell-free circulating tumor DNA in cancer.
Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason underlying difficulties in tumor treatment and failure of a number of current therapeutic modalities, even of molecularly targeted therapies. The development of a virtua...
متن کاملTP53 mutations on circulating cell-free DNA
Article history: Received 6 July 2016 Accepted 6 July 2016 Available online 8 July 2016 Besides the demand for higher sensitivity, the specificity of cfDNA measurements faces even more serious challenges. Cancer-associated mutations are thought to be restricted to cancer patients. However, Fernandez-Cuesta et al. observed cfDNA TP53-mutated fragments in 11.4% of 123 matched non-cancer controls....
متن کاملPlasma Circulating Cell-free Nuclear and Mitochondrial DNA as Potential Blood Biomarkers for Breast Cancer
Incidence rates of breast cancer are rising and mortality rates are proportionally high in Arab countries compared to rates in developed countries. The common late diagnosis among Arab women has been related to the low participation rates of Arab women in breast cancer screening activities (Donnelly et al., 2012). In Egypt, breast cancer is still considered number one killing cancer in females ...
متن کاملSimultaneous quantitative assessment of circulating cell-free mitochondrial and nuclear DNA by multiplex real-time PCR
Quantification of circulating nucleic acids in plasma and serum could be used as a non-invasive diagnostic tool for monitoring a wide variety of diseases and conditions. We describe here a rapid, simple and accurate multiplex real-time PCR method for direct synchronized analysis of circulating cell-free (ccf) mitochondrial (mtDNA) and nuclear (nDNA) DNA in plasma and serum samples. The method i...
متن کاملCirculating Cell-Free Mitochondrial DNA as Biomarker of Cardiovascular risk: New Challenges of Old Findingsi
Cardiovascular (CV) disease remains a major cause of mortality and morbidity worldwide, a widely spread illness worldwide and associated with increasing mortality within last decades [1]. Therefore, the high burden of CV and metabolic risk factors in different countries may have been affected the increased incidences of death in subjects prior to documentation of CV disease. In this context, it...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Psychoneuroendocrinology
سال: 2019
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2019.03.026